TNF and Sepsis: However early TNF-α concentrations were significantly higher, and there was a trend towards higher IL-8 values (p = 0.078) in patients who had died at 30 days compared to survivors (Table S5, Plasma cytokine and N/OFQ concentrations and mRNA expression for NOP and ppNOC, on Day 1 in patients admitted to ICU with sepsis, analysed according to 30-day mortality).