The current meta-analysis suggests a significant relationship between TNF-α-308G/A gene polymorphism and silicosis risk under the dominant genetic model for 1.45(95%CI: 1.20-1.760), but no significant association is found under the recessive genetic model (OR=0.77, 95%CI: 0.46-1.29). The gene discussed is TNF; the disease is silicosis.