SULF2 and metastatic malignant neoplasm in the lymph nodes: Using both univariate and multivariate Cox proportional hazard analysis that took into account age, sex, tumor site, stage, histological grade, lymph node metastasis and SULF2 methylation as covariates, tumor site and SULF2 methylation remained significant markers of overall survival in gastric cancer patients treated with platinum-based chemotherapy (Table 6).