SPI1 and Gaucher disease: In addition, affected Gaucher disease patients had increased serum levels of pro-inflammatory cytokines, i.e., TNF-α, IL-6, IL-8, IL-1β, sIL-2R and anti-inflammatory cytokines i.e., IL-1rn, sCD14 [71]–[74], which could be the result of PU.1/GATA1 reciprocal effects in the erythropoietic/myelopoietic system and lead to a general lower- expression profiles of genes involved in erythroid proliferation and development [75].