A comparison of Valpha24+ iNKT cells that are positive for 6B11 (Figure 3) with the subset of conventional T cells that are positive for Valpha24+ but negative for 6B11 confirms that even among Valpha24+ T cells, only the subset of 6B11+ cells express high levels of p-NF-κB and A2ARs. These findings support the conclusion that tissue injury in SCD generates lipid antigens that are uniquely capable of activating the invariant TCRs found on iNKT cells but not conventional T cells. The gene discussed is NFKB1; the disease is Schnyder corneal dystrophy.