Similarly, CTGF upregulation was found to be associated with apoptosis and decrease of tumor cell invasion [52]–[54]; PPM1A (PP2C) expression could induce cell cycle arrest and apoptosis via activation of the p53 pathway [55], and NF2 has been characterized as a TSG in different cancers [56]–[58]. This evidence concerns the gene NF2 and neoplasm.