Some of these gene nodes have been shown to be functionally involved in other cancer types, including regulation of tumor cell proliferation (Creb, C/ebp, ATF3, ATF4) [72]–[75], invasion (MTHFD2, FGF2) [76], [77] and metastasis (PTGS1/COX1, E-selectin, ATF3, FGF2, IL1A, MMP1, MMP13) [78]–[83]. Here, MMP1 is linked to cancer.