GDF15 and neoplasm: In parallel, upon RUNX2 knockdown, we have observed a predominant and strong downregulation of gene nodes known to be implicated in EOC tumorigenesis (PTGS1/COX1, FGF2, IL1A, Sapk, C/ebp, SELE, UBQLN1, PSAT1, ALDH1A1, GDF15, MTHFD2) [59]–[68], including EOC tumor invasion/metastasis (MMP1, MMP13, Creb) [69]–[71]; (see Figure 7B).