Alternatively, an attractive secreted protein that could mediate the effect of PTRF on angiogenesis is caveolin-1, which is increased in the serum of prostate cancer patients [41], has been shown to exert paracrine proangiogenic effects [42], and can be antagonized by caveolin-1 antibody [43;44]. The gene discussed is CAV1; the disease is Familial prostate cancer.