While this does not preclude the possibility that the ratio of secreted caveolin-1 to cellular caveolin-1 is reduced when PTRF allows caveola formation, in our experiments the protection afforded by PTRF in terms of angiogenesis and lymphangiogenesis cannot be attributed to the amount of caveolin-1 that the prostate cancer cells secrete. This evidence concerns the gene CAV1 and prostate carcinoma.