SMG1 and early-onset autosomal dominant Alzheimer disease: To determine if FUdR conferred protection in age-dependent models of protein misfolding, we examined a temperature-sensitive strain (CL4176 [smg-1(cc546ts);dvIs27(myo-3::Aβ3-42 let 39UTR(pAF29))]) in which the toxic peptide associated with Alzheimer's disease, Aβ, is expressed in muscle and leads to eventual paralysis [17].