MTOR and neoplasm: Our observation of a decreased polyclonality, coupled with an increase in the regional heterogeneity of T cell clones in the small number of tumours pretreated with the immunosuppressive mammalian target of rapamycin (mTOR) inhibitor everolimus, compared to the tumours which were untreated or treated with the anti-angiogenic drug sunitinib, may indicate that specific cancer therapies can influence the T cell repertoire and its distribution in solid tumours.