CD44 and neoplasm: This is in line with a study on colorectal adenocarcinoma by Bánky et al., where high expression levels of CD44v3 and CD44v6 were found to be characteristic to metastatically potent tumor cells, and CD44 variant isoforms were described to act as “metastasis genes” via tumor microenvironment-driven shifts in v3 and v6 expressions [35].