According to the Multicenter International Study of Oxaliplatin, 5-Fluorouracil and Leucovorin in the Adjuvant Treatment of Colon Cancer (MOSAIC) study, the reported incidences of OPN were as follows: grade 1 (48 %), grade 2 (32 %), and grade 3 (12 %) [1]. Here, SPP1 is linked to malignant colon neoplasm.