SPP1 and colonic neoplasm: According to the Multicenter International Study of Oxaliplatin, 5-Fluorouracil and Leucovorin in the Adjuvant Treatment of Colon Cancer (MOSAIC) study, the reported incidences of OPN were as follows: grade 1 (48 %), grade 2 (32 %), and grade 3 (12 %) [1].