TNF and early-onset autosomal dominant Alzheimer disease: IL-1β is the most significant pro-inflammatory cytokine which has increased in patients with neural degeneration including multiple sclerosis (MS), Alzheimer Disease (AD), Huntington and also Parkinson.9,10 In simulated animals with Alzheimer Disease, cerebrovascular injuries and traumatic brain, cytokines such as TNF-α, IL-1β and IL-6 could play important roles in hippocampus neurodegeneration.9-12