TTR misfolding and aggregation are associated with amyloid diseases such as senile systemic amyloidosis, familial amyloid polyneuropathy and familial amyloid cardiomyopathy (Rochet & Lansbury, 2000 ▶; Buxbaum & Tagoe, 2000 ▶; Kelly, 1996 ▶; Benson, 1989 ▶). Here, TTR is linked to amyloidosis.