A number of ribosomopathies, including Diamond Blackfan anemia, 5q syndrome, and Treacher Collins syndrome, all result in misregulation of p53, probably due to impaired ribosome production increasing the amount of nonribosomal 5S RNP (Figure 7; Fumagalli and Thomas, 2011). This evidence concerns the gene TP53 and Diamond-Blackfan anemia.