TP53 and myelodysplastic syndrome associated with isolated del(5q): A number of ribosomopathies, including Diamond Blackfan anemia, 5q syndrome, and Treacher Collins syndrome, all result in misregulation of p53, probably due to impaired ribosome production increasing the amount of nonribosomal 5S RNP (Figure 7; Fumagalli and Thomas, 2011).