VHL and renal cell carcinoma: We explored the role of Cav-1 in RCC tumorigenic potential through in-vitro studies in the 786-O (VHL-/- and PTEN-/-), A498 (VHL-/- and PTEN+/+) and caki-1 (VHL+/+ and PTEN+/+) cell lines all of which are of clear cell origin.