This compared to a DFS: of 5.27 yrs (P = 0.001) where tumours were Cav-1 positive and pERK-1/2 negative (C+/E- n = 26); of 4.77 yrs (P = 0.001) where tumours were pERK-1/2 positive and Cav-1 negative (C-/E + n = 37), and of 3.33 yrs (P = 0.001) where tumours co-expressed pERK-1/2 and Cav-1 (C+/E + n = 29). The gene discussed is CAV1; the disease is neoplasm.