CAV1 and neoplasm: Multivariate Cox regression analysis (Table 3) found only tumour grade (HR = 3.4; P = 0.001), capsular invasion (HR = 5.4; P < 0.001) and combined expression of Cav-1 and pERK-1/2 (HR = 4.2; P < 0.001) showed significant association with reduced DFS.