Stratifying patients into four subgroups according to the expression of tumour Cav-1 and pERK-1/2 (Figure 1L) revealed that tumours lacking expression of both Cav-1 and pERK-1/2 (C-/E- n = 64) were associated with a good prognosis, i.e. DFS of 6.75 yrs and an 80% probability of remaining disease-free at 5 yrs. The gene discussed is CAV1; the disease is neoplasm.