CAV1 and renal cell carcinoma: Cav-1 siRNA down-regulation resulted in an approximate 25% reduction (P = 0.05) in VEGF-A secretion (Figure 4A) in the VHL-negative 786-O and A498 RCC cell lines, while no significant effect upon VEGF-A secretion was seen in the VHL-positive caki-1 cells.