Three years later, the ovarian cysts recurred, and her endocrinological profile was FSH 10.92 mIU/ml, LH <0.10 mIU/ml (normal range for follicular phase, 1.76-10.24 mIU/ml), estradiol 304 pg/ml, and prolactin 56.68 ng/ml (normal range, 4.91-29.32 ng/ml), which indicated that the serum FSH and estradiol levels were within the normal ranges, and serum LH level was significantly suppressed. The gene discussed is PLOD1; the disease is Ovarian cyst.