THY1 and glomerulosclerosis: As shown in Table 1, animals with chronic anti-thy1 glomerulosclerosis showed significant increases in blood creatinine (2.43 ± 2.12 mg/dL) and urea concentrations (232 ± 182 mg/dL) and decrease in creatinine clearances (0.24 ± 0.16 mL/min) (all P < 0.01 vs. 1-K Control), indicating chronic renal insufficiency.