Previous studies have shown that beneficial effects of Imatinib in some models of renal fibrosis, such as acute anti-thy1 glomerulonephritis of the rat [15], lupus nephritis [26,27], hypertensive nephropathy [28], diabetic nephropathy [19], unilateral ureteral obstruction [29], chronic allograft nephropathy [30]. This evidence concerns the gene THY1 and diabetic kidney disease.