THY1 and kidney disorder: The major findings are 1) Imatinib remarkably limits the progressive course of chronic anti-thy1 antibody-induced renal disease as shown by functional and morphological estimates; 2) the renoprotective action of Imatinib involved beneficial effects on key pathways of progressive renal disease such as decreased TGF-beta protein expression, matrix protein accumulation, renal cell proliferation, myofibroblast activation and inflammatory cell infiltration; 3) these actions were most prominent in the tubulointersitial compartment and less in the glomerular space.