More importantly, Table 4 shows the results of logistic regression analyses conducted to identify factors that independently associate with severe AAC (KI > 5), which corroborated the significant independent association of age, CKD stage, male gender, and the presence of CP with severe AAC (KI > 5), and also with the log2(FEP/FGF23) < log2(1/3.9). The gene discussed is FGF23; the disease is chronic kidney disease.