The effect of the SOD2 gene Val16Ala polymorphism on macroalbuminuria was evaluated using a logistic regression model including sex, duration of T2D, body mass index, systolic blood pressure, diastolic blood pressure, current or previous smoking, HbA1c, total cholesterol, HDL-cholesterol, LDL-cholesterol, previous diagnosis of hypertension and hypertension treatment as covariates (all these variables were significantly associated with macroalbuminuria in our preliminary univariate analyses). The gene discussed is SOD2; the disease is type 2 diabetes mellitus.