This module also includes several genes previously associated with age or age-associated diseases such as the mitotic checkpoint protein BUB3, previously associated with accelerated aging in mice (Baker et al., 2006), and the cell-cycle checkpoint protein APPBP1 found in increased quantities in the brain affected by Alzheimer’s disease (Chen et al., 2003). The gene discussed is BUB3; the disease is early-onset autosomal dominant Alzheimer disease.