The effect of GW3965 (10 μM) on CXCL10 mRNA production was therefore studied at 6 h; LPS-induced expression of CXCL10 mRNA was inhibited by 40% from S and 38% from COPD patients (p=0.08 and p=0.008 respectively) (Figure 7). This evidence concerns the gene CXCL10 and chronic obstructive pulmonary disease.