Importantly, our results are in keeping with previous studies that showed that anti-PlGF antibody (5D11D4) could reduce angiogenesis and inflammation in preclinical tumour 26 and age-related macular degeneration models 28, whereas inhibition of VEGF-R2 only had an effect on neovascularization. The gene discussed is PGF; the disease is age-related macular degeneration.