DOCK8 and hyperinsulinemic hypoglycemia, familial, 4: In the B-cell compartment, marginal zone B cells are lacking in both WAS and DOCK8 deficiency, and B cells in both syndromes have poor IS formation due to a failure to concentrate LFA-1 and ICAM-1 in the pSMAC (peripheral supramolecular activation cluster) 55,156.