IGHE and Increased total eosinophil count: Clinical characteristics of DOCK8 deficiency include severe food or environmental allergies, otitis media, pneumonia, or bronchitis, eczema, eosinophilia, IgE dysregulation, and severe cutaneous viral infections, with the most common culprits being human papilloma virus (HPV), molluscum contagiosum virus, herpes simplex virus, and varicella-zoster virus 157,158.