In mice, adenoviral-mediated epithelial overexpression of smad2, a TGF-β and activin A signaling molecule, potentiates remodeling and AHR, without exacerbating the eosinophilia and Th2 inflammation in response to the common aeroallergen, house dust mite 5. This evidence concerns the gene AHR and Increased total eosinophil count.