MT-ND6 and Leber hereditary optic neuropathy: Examples of mouse models with mtDNA mutations include the Mito-mouse harbouring a heteroplasmic single mtDNA deletion at high mutation load (Inoue et al., 2000), and a mouse model of Leber's hereditary optic neuropathy (LHON) containing the ND6 P25L human mtDNA mutation (Lin et al., 2012).