In particular, the adipocytes derived from overweight/obese subjects, without or with CRC (1.10+0.15 OD and 1.26+0.19 OD, respectively), as well as those from NWCC subjects (1.73+0.40 OD), showed significantly lower levels of PPARγ compared to NW individuals (3.11+0.23 OD; P<0.01) (Figure 1B). The gene discussed is PPARG; the disease is colorectal carcinoma.