A recent analysis by Shankar et al using data from the Third National Health and Nutrition Examination Survey of 5,820 representative adults in the United States found the odds of CKD to be 3.25 (95% CI: 1.61, 6.55) times higher in the highest quartile of leptin compared to the lowest quartile after adjusting for relevant covariates [14]. The gene discussed is LEP; the disease is chronic kidney disease.