By intrahepatic injection CD90+ and CD90- JHH-6 cells to NOD/SCID mouse, even though no visible HCC nodules were noticed 4 months after injection, we observed that murine Afp mRNA expression in the liver of mouse injected with CD90+ was around 3 times higher compared to CD90-, meanwhile the albumin mRNA in lung was strikingly up-regulated compared to both CD90- and control mice (Figure S5 in File S1). The gene discussed is THY1; the disease is hepatocellular carcinoma.