In order to find out where this extra Grb2 was going, we investigated the levels of autophagy related proteins in STHdhQ111/111 cells and the two autophagy markers LC3, Beclin1 and late endosomal marker Rab7 were found to be significantly upregulated in the HD cell model (Figure 2C,D; p<0.01; n=3; for all). This evidence concerns the gene MAP1LC3A and Huntington disease.