Taking into account that the frequency of the rs2004640*T and rs10954213*A alleles is lower in the group of patients without macular edema than in those presenting this trait, it could be speculated that patients without edema present decreased IRF5 levels and, therefore, lower levels of inflammatory cytokines involved in the development of macular edema, including TNF- α and IL-6. The gene discussed is IRF5; the disease is edema.