Interestingly, several studies have reported that the treatment with type I IFNs (IFN-β-1 and IFN-α-2a) leads to complete or partial resorption of macular edema in a high percentage of uveitis patients [27,28], thus supporting the key role of the IFN signaling in this trait. The gene discussed is IFNB1; the disease is macular retinal edema.