These four genes comprise a key regulator of NF-κB signaling itself (IKBKB) and established mediators of the NF-κB cell-survival and pro-inflammatory responses (MMP9, PSMB9, and SOD2), raising the exciting possibility that selectively targeting members of this subset will have clinical benefit in ccRCC. The gene discussed is PSMB9; the disease is nonpapillary renal cell carcinoma.