NFKB1 and nonpapillary renal cell carcinoma: In this regard, initial studies have shown that small-molecule inhibition of NF-κB sensitizes otherwise-resistant ccRCC cells to (1) the tumoricidal activity of EGFR inhibitors, (2) apoptosis by the anti-tumor cytokine TRAIL, and (3) oncolysis by encephalomyocarditis virus [14,18–21].