Next, the PTS was calculated based on the pathological score, using the formula PTS=0.1132686p1+0.5076026p2+ (-)0.3791288p3, where p1, p2 and p3 corresponded to the pathological score of the pim-1 expression in tumor, tumor-adjacent mucosa and tumor stroma, respectively. The gene discussed is PIM1; the disease is neoplasm.