PLCE1 and esophageal cancer: Additionally, in the analysis stratified by cancer types (Figure 2), the PLCE1 rs2274223 polymorphism was significantly linked to a higher risk for esophageal cancer (GA vs. AA: OR = 1.22, 95% CI = 1.10–1.34, P<0.001, I2 = 39.60%; GG vs. AA: OR = 1.31, 95% CI = 1.10–1.55, P = 0.002, I2 = 0%; GG/GA vs. AA: OR = 1.24, 95% CI = 1.13–1.36 P<0.001, I2 = 45.20%; GG vs. GA/AA: OR = 1.20, 95% CI = 1.02–1.40, P = 0.027, I2 = 0%).