A direct correlation between increased MMP levels and malignant phenotype has been reported in the literature [65]–[67] and attributed to an increased capacity of tumor cells to respond to hypoxia by avoiding apoptosis [39], [66], [68], evade anoikis, prevent ATP consumption by the hydrolytic activity of the ATPase, and excessive ROS production [69], and invade the basement membrane [66]. Here, DNAH8 is linked to neoplasm.