In addition, CD8+ T cells primed in the lung-draining mediastinal LN by DC are enriched for CCR5 and CXCR3 expression compared to T cells primed in other sites (62) and these receptors regulate T cell effector responses and their contraction after infections with influenza viruses or Mycobacterium tuberculosis (Mtb) (63). This evidence concerns the gene CD8A and infection.