IL18 and Sepsis: Although levels of IL-18 in the circulation are below 1 ng/mL in inflammatory diseases such as severe sepsis, in active phase of fHLH or EBV-HLH, serum IL-18 is usually in the range of 5–7 ng/mL, and in fHLH complicating XIAP gene mutations as well as in MAS complicating sJIA, levels of circulating IL-18 can be in 20–30 ng/mL range (32, 96– 98).