Also, the expression of key surface molecules by TR2-deficient Treg cells—namely CTLA-4, GITR (Tnfrsf18), [28],[29] and ICOS [30]—remained unchanged (Figure 7H) in contrast to our observations in the bone marrow chimera model presenting with a lethal autoinflammatory syndrome. This evidence concerns the gene ICOS and autoinflammatory syndrome.