ADARB1 and infection: These mice undergo a progressive decline in motor function resulting from the progressive loss of ADAR2-lacking AHCs over a period ranging from 2–3 months to 6–8 months of age (Hideyama et al, 2010); thus, if effective expression of the ADAR2 gene is achieved by AAV9-hADAR2 infection, motor dysfunction should be ameliorated through the prevention of the death of the AHCs.