VPS35 and Alzheimer disease: In this regard, VPS35 is also similar to LRRK2, since ‘tau pathology’, usually a post-mortem hallmark of AD, has been described in patients (Zimprich et al., 2004; Khan et al., 2005; Rajput et al., 2006; Ujiie et al., 2012) and animal models harbouring LRRK2 mutations (Li et al., 2009; Lin et al., 2010; Melrose et al., 2010).