MAPT and tauopathy: These results indicate that in addition to G2019S-LRRK2 carriers, tau hyperphosphorylation at T149 and T153 occurs in a range of human tauopathies, including so-called 4R-tauopathies, 3R-tauopathies and 3R + 4R tauopathies, and that phosphorylation of these epitopes is linked to pathology, since no staining was detected in unaffected brains or unaffected brain regions in tauopathies (data not shown).