These results indicate that in addition to G2019S-LRRK2 carriers, tau hyperphosphorylation at T149 and T153 occurs in a range of human tauopathies, including so-called 4R-tauopathies, 3R-tauopathies and 3R + 4R tauopathies, and that phosphorylation of these epitopes is linked to pathology, since no staining was detected in unaffected brains or unaffected brain regions in tauopathies (data not shown). This evidence concerns the gene LRRK2 and tauopathy.