Tauopathies include Alzheimer’s disease (AD), progressive supranuclear palsy (PSP), Pick’s disease (PiD), and frontotemporal dementia and parkinsonism linked to chromosome-17 with mutations in the tau gene (FTDP-17t), but tau inclusions are often observed in PD brains as well (reviewed in [32]). Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.