Affected carriers of LRRK2 mutations are generally clinically indistinguishable from individuals with idiopathic PD and primarily present with Lewy body pathology [3, 19, 26, 61], but neuropathology is pleomorphic and often includes hyperphosphorylated tau protein inclusions [10, 17, 18, 43, 55, 58, 61, 71, 75]. This evidence concerns the gene LRRK2 and Parkinson disease.