TARDBP and amyotrophic lateral sclerosis: In their study, moderate expression of hTDP-43 (about 2.5 fold) can promote cytoplasmic TDP-43 expression, TDP-43 truncation, TDP-43 phosphorylation and TDP-43 aggregation, which mimics the TDP-43 proteinopathy in CNS of FTLD/ALS.