TARDBP and proteostasis deficiencies: However, another study states that a transgenic worm develops TDP-43 proteinopathy by expressing WT-hTDP-43 [45,46] and that the C. elegans models with the WT or mutant (A315T, G290A, M337V, Q331K and C25) hTDP-43 expression captures some characteristics of FTLD/ALS, including TDP-43 aggregation, truncation and phosphorylation.