TNFRSF21 and amyotrophic lateral sclerosis: 26 Disruption of this complex by using 5D10 to block the binding of DR6 to p75NTR led to cortical neuron survival.26 As both DR6 and p75NTR are upregulated in ALS and SOD1 mice, DR6 may induce motor neuron death through binding to p75NTR.