In a mouse model of c-Myc-driven lymphoma, inhibition of autophagy with either CQ or ATG5 shRNA promotes tumor cell death by p53 activation.84 Stanton et al.85 show that the VEGF-C/NRP-2 axis is involved in the activation of autophagy, and VEGF-C or NRP-2 depletion contributes to cytotoxic drug-mediated cell death. The gene discussed is VEGFC; the disease is lymphoma.