GSK3B and hepatocellular carcinoma: We found a significant inverse correlation between Notch3 and pGSK3βSer9 proteins accumulation (Spearman ρ= −0.666, p<0.01) and a significant direct correlation between Notch3 and p21 proteins expression (Spearman ρ= 0.681, p <0.01) (Fig.7) suggesting that Notch3 participates in the control of GSK3β phosphorylation and p21 expression in human hepatocellular carcinoma.