Correlations between expressions of TUBB3/STMN1 and gene mutations of epidermal growth factor receptor (EGFR), Kirsten rat sarcoma viral oncogene homolog (KRAS), v-raf murine sarcoma viral oncogene homolog B (BRAF), phosphatidylinositol-4, 5-bisphosphate 3-kinase (PI3K) in non-small cell lung cancer (NSCLC) would be investigated and this may provide essential significance on prognosis and predictions of drug efficiency. The gene discussed is KRAS; the disease is non-small cell lung carcinoma.