Furthermore, TNFα and IL1β treatment of Hep3B human hepatoma cells and mice resulted in decreased expression of RXRα, PPARα, PPARγ, LXRα, as well as their co-activators PGC1α and PGC-1β, which may contribute to the cytokine induced modulations in hepatic energy homeostasis [53]. Here, NR1H3 is linked to hepatocellular carcinoma.