In the 103 cases of ALCL, 62 (60%) were ALK positive, and either showed both cytoplasmic and nuclear staining indicative of the presence of NPM-ALK [49 cases, 79%, (Figure 1C), or cytoplasmic staining only indicating variant-ALK fusions 13 cases, 21%, (Figure 1D). This evidence concerns the gene ALK and anaplastic large cell lymphoma.