In ALK + ALCL cell lines and tumors, the mTOR signaling proteins, including mTOR, eukaryotic initiation factor 4E-binding protein-1 (4E-BP1), and the 70 kDa ribosomal protein S6 kinase polypeptide 1 (p70S6K1) kinase are highly phosphorylated [23]. The gene discussed is EIF4EBP1; the disease is anaplastic large cell lymphoma.