ALK and anaplastic large cell lymphoma: Inhibition of mTOR with rapamycin or silencing mTOR gene product expression using mTOR-specific small interfering RNAs decreased phosphorylation of the mTOR signaling proteins and induced cell cycle arrest and apoptosis in ALK + ALCL cells, indicating that blockage of the mTOR signaling pathway represents a potential therapeutic strategy in ALK + ALCL [22,23].