In the 39 ALK + ALCL cases showing cytoplasmic and nuclear staining, 30 (91%) were p-mTOR+, and 3 (9%) were p-mTOR-, and in the 11 ALK + cases showing cytoplasmic staining only, 9 (82%) were p-mTOR + and 2 (18%) were p-mTOR-. The gene discussed is MTOR; the disease is anaplastic large cell lymphoma.