In addition, a meta-analysis comparing 1,211 cases of schizophrenia with 1,729 controls found that the MTHFR p.Glu429Ala allele was associated with susceptibility to schizophrenia (Allen et al., 2008) (odds ratio, 1.19; 95% CI, 1.07–1.34; p = 0.002). The gene discussed is MTHFR; the disease is schizophrenia.