Recently, Raulet’s group have demonstrated in mice that expression of retinoic acid early inducible gene 1 (Rae-1), an NKG2D-L, in cancer cell lines and proliferating normal cells is coupled to the cell-cycle regulation Thus, Rae-1 is directly transcriptionally activated by E2F family transcription factors, which control the G1/S transition, and then play a central role in the cell-cycle entry (24). The gene discussed is RAE1; the disease is cancer.