Our results also suggest a previously unknown pathogenesis of dystonia induced by abnormal cerebellar activity in mice, namely BG-independent dystonia, based on the following facts; no apparent motor abnormality of BG-specific IP3R1 conditional mice, no difference in CO staining intensity in Itpr1flox/flox and Wnt1-Cre;Itpr1flox/flox mouse's BG, little correlations of BG activity and dystonic movement, and the ineffectiveness of pharmaceutical BG inactivation on dystonia of Wnt1-Cre;Itpr1flox/flox mice. Here, ITPR1 is linked to Dystonia.